Dr. O’Keefe is a practicing emergency physician in Sarasota, Florida. He is the founder, and current Program Director, for the Florida State University College of Medicine Emergency Medicine Residency. He started the University of South Florida Emergency Medicine Residency at Tampa General Hospital, and directed that program from 2000-2017.

In addition, he was the Program Director for the US Air Force side of the Joint Military Medical Centers Emergency Medicine Residency Program in San Antonio, Texas, from 1990-1995. He has additional leadership experience as an emergency department Medical Director at several hospitals. Dr. O’Keefe has spoken at the national level for ACEP for many years, and has published numerous times in Emergency Medicine textbooks and journals.